Journal of Veterinary Medical Science | |
Infectivity of Cryptosporidium andersoni and Cryptosporidium muris to Normal and Immunosuppressive Cynomolgus Monkeys | |
Chieko KAI2  Takeshi KURAISHI2  Yasuhiro FUKUDA1  Yutaka NAKAI1  Koichi MASUNO4  Ryo IKARASHI1  Junpei KIMURA3  Shosaku HATTORI2  Masahito KUBO5  Tokuma YANAI5  | |
[1] Laboratory of Sustainable Environmental Biology, Graduate School of Agricultural Science, Tohoku University, Naruko-Onsen, Osaki, Miyagi 989�?6711, Japan;The Institute of Medical Science, The University of Tokyo, 4�?6�?1 Shirogane-dai, Minato-ku, Tokyo 108�?8639, Japan;Korea Secretary General of Asian Society of Zoo and Wildlife Medicine, College of Veterinary Medicine, Seoul National University, Seoul 151�?742, Korea;Drug Developmental Research Laboratories, Shionogi & Co., Ltd., 3�?1�?1, Futaba-Cho, Toyonaka, Osaka 561�?0825, Japan;Veterinary Medicine, Gifu University, 1�?1 Yanagido, Gifu, Gifu 501�?1194, Japan | |
关键词: Cryptosporidium; experimental animals; monkey; parasitology; pathology; | |
DOI : 10.1292/jvms.13-0350 | |
学科分类:兽医学 | |
来源: Japanese Society of Veterinary Science | |
【 摘 要 】
References(23)Cited-By(1)Cryptosporidium andersoni and Cryptosporidium muris infections have been found in the mice and/or cattle. The oocysts of C. andersoni and C. muris have been sporadically detected in human feces, but the infectious capacity and features have been unknown, because of the scarcity of reports involving human infections. To assess the infectivity and the clinical and pathological features of C. andersoni and C. muris in primates, an experimental infectious study was conducted using cynomolgus monkeys. The monkeys were orally inoculated with oocysts of two different C. andersoni Kawatabi types and C. muris RN-66 under normal and immunosuppressive conditions. The feces of the monkeys were monitored for about 40 days after the administration of oocysts using the flotation method, but no shedding oocysts were observed under either both normal or immunosuppressive conditions. Gross and histopathological examinations were performed on the immunosuppressive monkeys, but these revealed no evidence of Cryptosporidium infections, even though the monkeys were subjected to immunosuppressive conditions. It is hypothesized that C. andersoni and C. muris pose little danger of infection in primates even under immunosuppressive conditions.
【 授权许可】
Unknown
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