Journal of Veterinary Medical Science | |
Optimal Dose of Enterococcal Preparation (FK-23) Supplemented Perorally for Stimulation of Leukocyte Reconstitution in Dogs Treated with Cyclophosphamide | |
Tetsurou YAMAMOTO1  Hideyo YAMAGUCHI1  Takashi HASEGAWA1  Shigeru ABE1  Hiromi KANASUGI1  | |
关键词: Enterococcus faecalis; leukopenia; reconstitution; | |
DOI : 10.1292/jvms.58.563 | |
学科分类:兽医学 | |
来源: Japanese Society of Veterinary Science | |
【 摘 要 】
References(6)Cited-By(3)Optimal doses of orally supplemented heat-killed Enterococcus faecalis FK-23 preparation (FK-23) were evaluated in dogs treated with cyclophosphamide (CY). Leukocyte reconstitution was stimulated by the supplement of 100 mg/kg of FK-23 through an induction of neutrophilia, and the treatment of 10 mg/kg of FK-23 induced mild neutrophilia in dogs tested. However, the reconstitution was not stimulated by the treatment of 200 or 400 mg/kg of the drug. Although the effects of FK-23 appeared to be milder than those of recombinant human granulocyte colony stimulating factor (rhG-CSF), there was no significant difference in the leukocyte reconstitution between the two substances. An appropriate dose of FK-23 is 100 mg/kg for augmentation of leukocyte reconstituting capacity in dogs treated with CY.
【 授权许可】
Unknown
【 预 览 】
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RO201911300059331ZK.pdf | 479KB | download |