Effect of Orally Administered Heat-Killed Enterococcus faecalis FK-23 Preparation on Leukopenia in Mice Treated with Cyclophosphamide

Journal of Veterinary Medical Science

Takateru INOMATA¹  Tetsuro YAMAMOTO¹  Yukari OGURA¹  Hideyo YAMAGUCHI¹  Yuko MURAKUMO¹  Takashi HASEGAWA¹  Shigeru ABE¹ 

关键词: heat-killed Eriterococcus faecalis;    leukopenia;    reconstitution;   

DOI  :  10.1292/jvms.56.1203

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(12)Cited-By(7)Cyclophosphamide (CY) treated mice were orally administered heat-killed Enterococcus faecalis FK-23 preparation (FK-23) to define the effect of FK-23 on leukopenia associated with chemotherapy. FK-23 had no inhibiting effect on CY induced leukopenia, whereas it augmented leukocyte reconstitution in CY-treated mice. The percentage of neutrophils increased in the mice orally given FK-23. Furthermore, an increase in a myeloid/erythroid ratio and neutrophilic lineages was found in bone marrow of FK-23 treated mice. These findings suggest that FK-23 may have a potent effect on the augmentation of leukocyte reconstituting capacity in patients receiving chemotherapy.

【 授权许可】

Unknown