Treatment with α-Glucosidase Inhibitor for Severe Reactive Hypoglycemia

Endocrine Journal

TAKAO TAKIZAWA¹  YASUE OMORI¹  SHINICHI TENO¹  YUKO NAKAJIMA-UTO¹  MADOKA SHIMIZU-SAITOH¹  KAZUTAKA NAGAI¹  HIROYUKI OZU¹ 

[1] Saitamaken Saiseikai Kurihashi Hospital

关键词: Alimentary hypoglycemia;    Post-gastrectomy;    Chronic renal failure;    α-Glucosidase inhibitor;    Counterregulatory hormone;   

DOI  :  10.1507/endocrj.47.437

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(35)Cited-By(6)Gastrectomy or vagotomy may result in reactive hypoglycemia, which, in some cases, can reduce the plasma glucose levels to 30-40mg/dl due to rapid digestion and absorption of food, especially carbohydrates. It also occurs sometimes in patients on hemodialysis, where it is a potentially lethal complication. Because insulin has a longer half-life due to lack of renal degradation, hypoglycemia can be induced by insulin in patients with renal failure. We treated a patient with frequent episodes of severe hypoglycemia, that were sometimes accompanied by convulsions. He had undergone total gastrectomy 8 years before and had been maintained on hemodialysis for 3 years. Hyperinsulinemia caused by oxyhyperglycemia associated with post-gastrectomy led to severe hypoglycemia in this patient because of the lack of renal insulin degradation. Since nutritional treatment did not successfully manage his reactive hypoglycemia, an α-glucosidase inhibitor, acarbose, was administered to treat his oxyhyperglycemia. This therapy was very effective and he has not had any recurrence of reactive hypoglycemia since the initiation of the therapy.

【 授权许可】

Unknown