Synthesis and biological evaluation of stilbene derivatives coupled to NO donors as potential antidiabetic agents

Journal of Enzyme Inhibition and Medicinal Chemistry

Jie Sun¹  Zhongyu Wu¹  Lei Zhang¹  Teng Liu¹  Xiaojing Wang¹  Bing Wang¹ 

[1] School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, China;Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, China;Key Laboratory for Biotech-Drugs Ministry of Health, Jinan, China;Key Laboratory for Rare & Uncommon Diseases of Shandong Province, Jinan, Chin;

关键词: α-Glucosidase inhibitor;    antidiabetic;    AGEs formation inhibitor;    stilbene;    nitric oxide donor;   

DOI  :  10.1080/14756366.2018.1425686

来源: publisher

【 摘 要 】

The work is focused on the design of drugs that prevent and treat diabetes and its complications. A novel class of stilbene derivatives were prepared by coupling NO donors of alkyl nitrate and were fully characterised by NMR and other techniques. These compounds were tested in vitro activity, including α-glucosidase inhibitory activity, aldose reductase (AR) inhibitory activity and advanced glycation end products (AGEs) formation inhibitory activity. A class of modified compounds could play a significant effect for treatment of diabetic complications. Target compounds 3e and 7c offered a potential drug design concept for the development of therapeutic or preventive agents for diabetes and its complications.

【 授权许可】

CC BY