Effects of miglitol versus sitagliptin on postprandial glucose and lipoprotein metabolism in patients with type 2 diabetes mellitus

Endocrine Journal

Shun Ishibashi²  Hiroaki Yagyu²  Kazufumi Ozaki²  Shuichi Nagashima²  Manabu Takahashi²  Kazuhiko Kotani¹  Hisataka Yamazaki²  Jun-ichi Osuga²  Kenta Okada² 

[1] Department of Public Health, Jichi Medical University, Tochigi 320-0498, Japan;Department of Internal Medicine, Division of Endocrinology and Metabolism, Jichi Medical University, Tochigi 320-0498, Japan

关键词: α-Glucosidase inhibitor;    Cookie-loading test;    Dipeptidyl peptidase-4 inhibitor;    Postprandial hyperglycemia;    Postprandial hyperlipidemia;   

DOI  :  10.1507/endocrj.EJ13-0019

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(37)Cited-By(2)Postprandial hyperglycemia and/or hyperlipidemia can contribute to development of atherosclerosis in patients with type 2 diabetes mellitus (T2DM).The objective of this study was to compare the effects of miglitol and sitagliptin on postprandial glucose and lipid metabolism in patients with T2DM.Thirty-five patients with T2DM were randomized to 2 groups receiving miglitol (150 mg/day) or sitagliptin (50 mg/day).Serum variables related to glucose and lipid metabolism were measured before and after treatment for 10 weeks and at 0, 60, and 120 min using a cookie-loading test (CLT).After 10 weeks of treatment, miglitol (n = 16) and sitagliptin (n = 18) caused a similarly significant decrease in hemoglobin A1c (mean: 7.6% to 7.3% versus 8.0% to 7.6%) and a significant increase in fasting insulin levels, with a greater increase observed in the miglitol group than in the sitagliptin group (p=0.03).In addition, a significant decrease in the change in glucose levels after the CLT was observed in both groups, with a greater decrease observed in the miglitol group than in the sitagliptin group (p=0.02).The miglitol group also showed a greater decrease in the change in insulin levels after the CLT than the sitagliptin group (p<0.01).The lipid and lipoprotein levels did not show any significant differences between the groups after the CLT.Our results suggested that miglitol and sitagliptin treatment resulted in similar glycemic control but that a greater decrease in postprandial glucose and insulin levels was observed with miglitol compared with sitagliptin in patients with T2DM.

【 授权许可】

Unknown