Bisphenol-A Hepatotoxicity and the Protective Role of Sesame Oil in Male Mice

Jordan Journal of Biological Sciences

Osama H. Elhamalawy¹ 

关键词: Bisphenol-A;    Hepatotoxicity;    Sesame oil;    DNA damage;    Histopathological alterations;   

DOI  :  

学科分类：生物科学（综合）

来源: Hashemite University, Deanship of Research and Higher Studies

【 摘 要 】

The present study is conducted to estimate the protective effects of sesame oil (SO) against bisphenol-A (BPA) induced hepatotoxicity in male mice. BPA (50 mg/kg b wt) was gavages orally to mice once a day for twenty-eight successive days. While, SO was administered to the mice orally at 1 mL/kg b wt. through three regimens (before, with or after) treatment of BPA. After the complementation of treatments, the liver of each sacrificed animal was subject to DNA damage evaluation using alkaline comet assay and histopathological examination. In addition, blood was collected for biochemical assessment of the liver function. Results showed that, BPA significantly reduced the relative liver weight, and caused DNA damage, several histopathological alterations in liver tissue and elevation in ALT and AST compared to the control. On the contrary, oral gavages of SO with BPA was effective in the increase of relative liver weight, amelioration of DNA damage and histopathological alterations, and in the reduction of the liver enzyme levels compared to BPA's treated mice. Furthermore, the best alleviation of the undesirable effects of BPA appears in the administration of SO to mice before the BPA treatment, followed by after treatment and during or with BPA treatment. In conclusion, the present study provided clear evidence that SO possesses a promising protective activity against the noxious effects of BPA.

【 授权许可】

CC BY