Natural products as reservoirs of novel therapeutic agents

EXCLI Journal

Rashda Abbasi²  Bilal Haider Abbasi³  Bushra Uzair⁵  Sadaf Mushtaq⁶ 

[1] Applied Sciences, International Islamic University, Sector H-8, Islamabad, Pakistan;Biotechnology, Faculty of Basic &EA2106 Biomolécules et Biotechnologies Végétales, Université de Tours, 37200 Tours, France;Genetic Engineering (IBGE), Sector G-9/1, Islamabad, Pakistan;Department of Bioinformatics &Department of Biotechnology, Faculty of Biological Sciences, Quaid-i-Azam University Islamabad-45320, Pakistan;Institute of Biomedical &

关键词: bioactive;    secondary metabolites;    plants;    animals;    marine organisms;    microbes;   

DOI  :  10.17179/excli2018-1174

学科分类：过敏症与临床免疫学

来源: University of Mainz, University of Leipzig

【 摘 要 】

Since ancient times, natural products from plants, animals, microbial and marine sources have been exploited for treatment of several diseases. The knowledge of our ancestors is the base of modern drug discovery process. However, due to the presence of extensive biodiversity in natural sources, the percentage of secondary metabolites screened for bioactivity is low. This review aims to provide a brief overview of historically significant natural therapeutic agents along with some current potential drug candidates. It will also provide an insight into pros and cons of natural product discovery and how development of recent approaches has answered the challenges associated with it.

【 授权许可】

CC BY