Adipokine and cytokine levels in non-functioning adrenal incidentalomas (NFAI)

Endocrine journal

Anna Babinska¹  Mariusz Kaszubowski² 

[1] Department of Endocrinology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland;Institute of Statistics, Department of Economic Sciences, Faculty of Management and Economics, Gdansk University of Technology, Gdansk, Poland

关键词: Adipokines;    Cytokines;    Adrenal tumors;   

DOI  :  10.1507/endocrj.EJ18-0066

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

Due to the fact that overweight or obesity is accompanied by hormonally active adrenal tumors: Cushing Syndrome—(CS) and Subclinical Cushing Syndrome (SCS), it is of high interest the correlation between different adipokines and cytokines secreted by adipose tissue, with metabolic disorders and hormonal activity in this group. Even in non-functioning adrenal incidentalomas (NFAI) elevated risk for cardiovascular disease and metabolic syndrome was demonstrated. The aim of the study was to investigate plasma adiponectin, leptin, resistin, tumor necrosis factor α (TNFα), interleukin 6 (IL6) and monocyte chemoattractant protein 1 (MCP1) levels in patients with NFAIs and healthy subjects. The study included 18 NFAI patients and 18 healthy subjects. The groups were homogeneous in terms of age, sex and body mass index (BMI). Patients with NFAI showed significantly higher circulating levels of pro-inflammatory cytokines compared to healthy controls (MCP 1: p < 0.001; TNFα p = 0.021; IL6 p = 0.012). On the other hand, adiponectin concentration was significantly lower in the NFAI group (p = 0.034). The serum leptin and resistin concentrations did not differ significantly between the two groups. Acquired results were not dependent on glucocorticoid and catecholamine secretion in NFAI patients. Also, there were no clear correlations between BMI and cytokine levels. It is possible that increased risk for cardiovascular and metabolic diseases reported in NFAI patients is at least partially dependent on adipose tissue activity.

【 授权许可】

Unknown