Cerebrospinal fluid GAP-43 in early multiple sclerosis

Multiple Sclerosis Journal – Experimental, Translational and Clinical

URot¹ 

关键词: Multiple sclerosis;    cerebrospinal fluid;    biomarkers;    axonal loss;    axonal regeneration;    growth-associated protein 43;   

DOI  :  10.1177/2055217318792931

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Background/ObjectiveNovel biomarkers identifying and predicting disease activity in multiple sclerosis (MS) would be valuable for primary diagnosis and as outcome measures for monitoring therapeutic effects in clinical trials. Axonal loss is present from the earliest stages of MS and correlates with disability measures. Growth-associated protein 43 (GAP-43) is a presynaptic protein with induced expression during axonal growth. We hypothesized this protein could serve as a biomarker of axonal regeneration capacity in MS.MethodsWe developed a novel GAP-43 enzyme-linked immunosorbent assay for quantification in cerebrospinal fluid (CSF) and measured GAP-43 levels in 71 patients with clinically isolated syndrome, 139 MS patients and 51 controls.ResultsGAP-43 concentrations were similar in patients and controls. Nevertheless, GAP-43 levels were higher in patients with >10 T2-magnetic resonance imaging (MRI) lesions (p = 0.005). CSF GAP-43 concentrations correlated with CSF mononuclear cell counts (p = 0.031) a...

【 授权许可】

CC BY-NC