Tumor-Associated CSF MicroRNAs for the Prediction and Evaluation of CNS Malignancies

International Journal of Molecular Sciences

Tarek Shalaby²  Michael A. Grotzer¹ 

[1] Department of Oncology, University Children’s Hospital, CH-8032 Zurich, Switzerland

关键词: cerebrospinal fluid;    CNS cancers;    microRNA;    biomarkers;   

DOI  :  10.3390/ijms161226150

来源: mdpi

【 摘 要 】

Cerebrospinal fluid (CSF) is a readily reachable body fluid that is reflective of the underlying pathological state of the central nervous system (CNS). Hence it has been targeted for biomarker discovery for a variety of neurological disorders. CSF is also the major route for seeding metastases of CNS malignancies and its analysis could be informative for diagnosis and risk stratification of brain cancers. Recently, modern high-throughput, microRNAs (miRNAs) measuring technology has enabled sensitive detection of distinct miRNAs that are bio-chemicallystable in the CSF and can distinguish between different types of CNS cancers. Owing to the fact that a CSF specimen can be obtained with relative ease, analysis of CSF miRNAs could be a promising contribution to clinical practice. In this review, we examine the current scientific knowledge on tumor associated CSF miRNAs that could guide diagnosis of different brain cancer types, or could be helpful in predicting disease progression and therapy response. Finally, we highlight their potential applications clinically as biomarkers and discuss limitations.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.