Introduction of Diverse Functional Groups to Isoquinolines by Microwave‐assisted Transition Metal‐catalyzed Coupling Reactions

Bulletin of the Korean Chemical Society

A. Reum Park¹ 

[1] Department of Chemistry Chungnam National University Daejon 34134 Korea

关键词: Microwave;    Palladium;    Copper;    Coupling reaction;    Functionalization;    Disubstituted isoquinoline;   

DOI  :  10.1002/bkcs.11585

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Diverse functional groups were introduced in isoquinolines under microwave‐assisted palladium‐ or copper‐catalyzed coupling reactions, which include functional groups to isoquinoline were achieved with 1‐substituted 4‐ and 7‐bromoisoquinolines, arylboronic acids, terminal alkenes, terminal alkynes, and azaheterocycles. 1,4‐ or 1,7‐Disubstituted isoquinolines were obtained in moderate to excellent yields within 1 h under microwave irradiation. The facile functional group modification of isoquinoline core could establish isoquinoline compound library for drug discovery.

【 授权许可】

Unknown