Procaine as a New Coupling Agent for the Spectrophotometric Determination of Fibrates by Diazotization Coupling Reaction

2nd International Scientific Conference (Pure Sciences, Brilliant Creativity and Renewed Building)

Kahlol, Mohammed K.^1 ; Mashkoor, Muthana S.^1

Department of Chemistry, Faculty of Science, Kufa University, AL-Najaf, Iraq^1

关键词: Coupling reaction;    Diazotization;    Fibrates;    Limit of detection;    Molar absorptivity;    Pharmaceutical preparations;    Primary amine groups;    Spectrophotometric determination;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/571/1/012084/pdf
DOI  :  10.1088/1757-899X/571/1/012084

来源: IOP

【 摘 要 】

A sensitive, selective, rapid, simple and accurate of the spectrophotometry determination of fibrates in bulk and in dosage forms. This method depend on diazotization of primary amine group of procaine hydrochloric acid with sodium nitrate and hydrochloric acid followed by coupling with fibrates in aqueous mildly acidic medium to form azo dye stable orange-yellow. Showed obeyed beers law between 0.2-14 ppm, with molar absorptivity 3.01∗104L.mole-1.cm-1at 385nm. Sandells sensitivity 0.006mg.cm-1, limit of detection (LOD) 0.018ppm and limit of quantitication (LOQ) 0.058 ppm. This method has been successfully applied to determination of fibrates in bulk and in pharmaceutical preparation, tablet with a good recoveries 99.63-100.25 %