The Spectrophotometric Determination of Olanzapine via Coupling with Diazotized p-Nitroaniline

Iraqi Journal of Pharmaceutical Sciences

ARTICLE

Sahar R. Fadhel¹  Najwa I. Abdulla²  Intidhar D. Sulaiman² 

[1] Department of Chemistry, College of Science, University of Diyala;Department of Chemistry, College of Education for Pure Sciences (Ibn Al-Haitham), University of Baghdad

关键词: Spectrophotometry;    Olanzapine;    Diazotization;    p-nitroaniline;    tablet dosage form.;   

DOI  :  10.31351/vol25iss1pp42-49

学科分类：计算机网络和通讯

来源: College of Pharmacy University of Baghdad

【 摘 要 】

A new spectrophotometric method has been developed for the assay of olanzapine (OLN.) in pure and dosage forms. The method is based on the diazocoupling of (OLN.) with diazotized p-nitroaniline in alkaline medium to form a stable brown colored water-soluble azo dye with a maximum absorption at 405 nm. The variables that affect the completion of reaction have been carefully optimized. Beer’s law is obeyed over the concentration range of (0.5-45.0 μg.mL-1 ) with a molar absorptivity of 1.5777×104 L.mol-1 .cm-1 . The limit of detection was 0.3148 μg.mL-1 and Sandell’s sensitivity value was 0.0198 μg.cm-2 . The proposed method has been applied successfully to the determination of olanzapine in tablet pharmaceutical preparations.

【 授权许可】

CC BY