Suzuki-Miyaura cross-coupling of benzylic bromides under microwave conditions

TETRAHEDRON LETTERS

卷:52

Article

McDaniel, Steven W.¹  Keyari, Charles M.¹  Rider, Kevin C.¹  Natale, Nicholas R.¹  Diaz, Philippe¹ 

[1] Univ Montana, Core Lab Neuromol Prod, Dept Biomed & Pharmaceut Sci, Missoula, MT 59803 USA

关键词: Suzuki-Miyaura;    Cross-coupling;    Microwave;    Palladium;   

DOI  :  10.1016/j.tetlet.2011.08.096

来源: Elsevier

【 摘 要 】

A procedure for benzylic Suzuki-Miyaura cross-coupling under microwave conditions has been developed. These conditions allowed for heterocyclic compounds to be coupled. Optimum conditions found were Pd(OAc)(2), JohnPhos as the catalyst and ligand, potassium carbonate as base, and DMF as the solvent. Using these conditions, a library of structurally diverse compounds was synthesized. (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

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