Increased cystatin F levels correlate with decreased cytotoxicity of cytotoxic T cells

Radiology and Oncology

Jerica Sabotic^1¹  Mateja Prunk^1,2²  Milica Perisic Nanut^1³ 

[1] Blood Transfusion Centre of Slovenia, Ljubljana, Slovenia^3;Jožef Stefan Institute, Department of Biotechnology, Ljubljana, Slovenia^1;University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia^2

关键词: cystatin F;    cysteine cathepsins;    TALL-104;    TGFβ;    ionomycin;    anergy;   

DOI  :  10.2478/raon-2019-0007

学科分类：肿瘤学

来源: Onkoloski Institut Ljubljana / Institute of Oncology Ljubljana

【 摘 要 】

BackgroundCystatin F is a protein inhibitor of cysteine peptidases, expressed predominantly in immune cells and localised in endosomal/lysosomal compartments. In cytotoxic immune cells cystatin F inhibits both the major pro-granzyme convertases, cathepsins C and H that activate granzymes, and cathepsin L, that acts as perforin activator. Since perforin and granzymes are crucial molecules for target cell killing by cytotoxic lymphocytes, defects in the activation of either granzymes or perforin can affect their cytotoxic potential.

【 授权许可】

Unknown