Pooled analysis of T2 Candida for rapid diagnosis of candidiasis

BMC Infectious Diseases

  ^{1    1    1    1    2    2} 

[1] 0000 0000 8653 1072, grid.410737.6, Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, Guangzhou, Guangdong, China;0000 0000 8653 1072, grid.410737.6, Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, Guangzhou, Guangdong, China;0000 0004 1758 4591, grid.417009.b, Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China;Key Laboratory for Major Obstetric Diseases of Guangdong Province, 510150, Guangzhou, China;Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, 510150, Guangzhou, China;

关键词: T2 Candida;    Candida infection;    Diagnosis;    Meta-analysis;   

DOI  :  10.1186/s12879-019-4419-z

来源: publisher

【 摘 要 】

BackgroundThe present meta-analysis examined the diagnostic accuracy of T2 Candida for candidiasis.MethodsThe literature databases, such as PubMed, Embase, DVIO, Cochrane library, Web of Science, and CNKI, were searched on T2 Candida detection.ResultsA total of 8 articles, comprising of 2717 research subjects, were included in the study. The pooled sensitivity and specificity were 0.91 (95% confidence interval (CI): 0.88–0.94) and 0.94 95% CI: 0.93–0.95), respectively. The pooled positive likelihood ratio and negative likelihood ratio was 10.16 (95% CI: 2.75–37.50) and 0.08 (95% CI: 0.02–0.35), respectively. The combined diagnostic odds ratio is 133.65 95% CI: 17.21–1037.73), and the AUC of SROC is 0.9702 [(SE = 0.0235), Q* = 0.9201(SE = 0.0381)].ConclusionsThe current evidence supported that T2 Candida has high accuracy and sensitivity and is of major clinical significance in the diagnosis of Candida infection.

【 授权许可】

CC BY