A Meta-Analysis of the Diagnostic Accuracy of Circular RNAs in Digestive System Malignancy

Cellular Physiology and Biochemistry

Zhiqiang Chen¹ 

关键词: Circular RNA;    Digestive System Neoplasm;    Meta-analysis;    Diagnosis;    Biomarker;   

DOI  :  10.1159/000487291

学科分类：分子生物学，细胞生物学和基因

来源: S Karger AG

【 摘 要 】

Background/Aims Circular RNAs (circRNAs), a novel class of noncoding RNAs, have been found to be dysregulated in various cancers. However, the clinical application value of these circRNAs in digestive system cancers remains to be clarified. We aimed to comprehensively explore the potential role of circRNAs as diagnostic indicators in digestive system malignancies. Methods Relevant studies were systematically retrieved from PubMed, Web of Science and the Cochrane Library. The data that were required to complete 2 × 2 contingency tables were obtained from the included studies. Stratified analyses by cancer type, sample size and publication year were performed. Results Thirteen studies with 2,276 individuals were included in the meta-analysis. The pooled sensitivity and specificity of circRNAs in the diagnosis of digestive system malignancy were 0.72 [95% confidence interval (CI) 0.65-0.77] and 0.77 (95% CI 0.72-0.81), respectively. The overall positive likelihood ratio was 3.09 (95% CI 2.64-3.62), and the overall negative likelihood ratio was 0.37 (95% CI 0.31-0.44). The pooled diagnostic odds ratio was 8.38 (95% CI 6.86-10.25), and the overall area under the curve was 0.81 (95% CI 0.77-0.84), indicating good discriminative ability of circRNAs as biomarkers for digestive system malignancy. Conclusion circRNAs distinguish patients with digestive system cancer from controls with relatively high diagnostic accuracy. circRNAs may be used as potential biomarkers for the diagnosis of digestive system malignancy.

【 授权许可】

CC BY-NC-ND