Sleep experiences during different lifetime periods and in vivo Alzheimer pathologies

Alzheimer's Research & Therapy

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[1] 0000 0001 0302 820X, grid.412484.f, Center for Sleep and Chronobiology, Seoul National University Hospital, Seoul, Republic of Korea;0000 0004 0470 5905, grid.31501.36, Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea;0000 0001 0302 820X, grid.412484.f, Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea;0000 0001 0302 820X, grid.412484.f, Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea;0000 0004 0470 5905, grid.31501.36, Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea;0000 0001 0302 820X, grid.412484.f, Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea;0000 0004 0470 5112, grid.411612.1, Department of Psychiatry, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea;0000 0004 0470 5905, grid.31501.36, Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Republic of Korea;0000 0004 0647 2279, grid.411665.1, Department of Neuropsychiatry, Chungnam National University Hospital, Daejeon, Republic of Korea;0000 0004 1790 2596, grid.488450.5, Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Republic of Korea;grid.412479.d, Department of Nuclear Medicine, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea;

关键词: Midlife sleep;    Preclinical Alzheimer’s disease;    Cerebral amyloid;    Neurodegeneration;   

DOI  :  10.1186/s13195-019-0536-6

来源: publisher

【 摘 要 】

BackgroundVery little is known for the direction or causality of the relationship between lifetime sleep experiences and in vivo Alzheimer’s disease (AD) pathologies. This study aimed to examine the relationship between sleep experiences during the young adulthood, midlife, and late-life periods and in vivo cerebral beta-amyloid (Aβ) deposition and AD signature regional neurodegeneration in cognitively normal (CN) old adults.MethodsThis study included 202 CN old adults who participated in the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer’s Disease (KBASE) study. All participants underwent a comprehensive clinical assessment, [11C] Pittsburgh Compound B positron emission tomography (PET), [18F] Fluorodeoxyglucose-PET, and magnetic resonance imaging. The quality and duration of sleep were assessed for the following age periods: 20–30s, 40–50s, and the most recent month. All analyses were adjusted for age, gender, education, apolipoprotein E ε4 status, vascular risk score, Hamilton Depression Rating Scale score, and use of sleep medication.ResultsBad sleep quality and short sleep duration during midlife were significantly associated with increased Aβ deposition and AD signature regional hypometabolism, respectively. Although current bad sleep quality appeared to be associated with increased Aβ accumulation, this association disappeared after controlling for the effects of midlife sleep quality. Neither the quality nor duration of sleep during young adulthood was related to Aβ burden or neurodegeneration.ConclusionsBad sleep quality during midlife increases pathological Aβ deposition in the brain, while short sleep duration during the same period accelerates regional hypometabolism.

【 授权许可】

CC BY