Coronary risk correlates with cerebral amyloid deposition

NEUROBIOLOGY OF AGING

卷:33

Article

Reed, Bruce R.^1,2  Marchant, Natalie L.^3,4  Jagust, William J.^3,4  DeCarli, Charles C.¹  Mack, Wendy⁵  Chui, Helena C.⁶ 

[1] Univ Calif Davis, Dept Neurol, Sch Med, Davis, CA 95616 USA

[2] Vet Affairs No Calif Hlth Care Syst, Martinez, CA USA

[3] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

[4] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Life Sci, Berkeley, CA 94720 USA

[5] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA

[6] Univ So Calif, Keck Sch Med, Dept Neurol, Los Angeles, CA 90033 USA

关键词: Vascular risk factors;    Coronary risk factors;    Cerebral amyloid;    Mild cognitive impairment;    Normal aging;    Alzheimer's disease;   

DOI  :  10.1016/j.neurobiolaging.2011.10.002

来源: Elsevier

【 摘 要 】

This study investigated the hypothesis that vascular risk factors are amyloidogenic. Participants were 43 persons, most with normal cognition or mild cognitive impairment. Vascular risk was quantified using the Framingham Coronary Risk Profile (FCRP) score. Cerebral amyloid was measured by [C-11] Pittsburgh compound B (PIB) positron emission tomography (PET) and quantified with a Global PIB index, which is the average of distribution volume ratios in selected cortical regions of interest. In a bivariate model FCRP accounted for 16% of the variance in PIB index (p < 0.008) and the positive association remained significant controlling for age and sex. The effect of FCRP was independent of apolipoprotein E (APOE) genotype, which was also associated as expected with PIB. Carotid intima-media thickness was not associated with PIB index. Effects of individual FCRP component risk factors, cholesterol, and glycemic status on PIB index were all nonsignificant, suggesting an aggregate effect of risk factors. Although this is a correlational observation it may represent a causal relationship as there are multiple, plausible, amyloidogenic mechanisms of vascular risk factors. Published by Elsevier Inc.

【 授权许可】

Free