Iranian Journal of Pharmaceutical Research | |
Methadone concentrations in exhaled breath condensate, serum and urine of patients under maintenance treatment | |
关键词: methadone; exhaled breath condensate; HPLC; Serum; Urine; correlation; | |
DOI : | |
学科分类:社会科学、人文和艺术(综合) | |
来源: Shaheed Beheshti Medical University * School of Pharmacy | |
【 摘 要 】
Drug abuse is a serious problem causing health, economical and psycho-social negative outcomes. Methadone is commonly used drug for management of drug addiction. Exhaled breath condensate (EBC) is a promising non-invasive biological sample which attracted more attention in recent years. This work aimed to extend the applicability of a developed preconcentration â liquid chromatographic method for analysis of methadone in serum and urine samples. Drug concentrations in EBC, serum and urine are also investigated for dose-concentration and their inter-correlations. Biological samples were collected from 53 patients receiving methadone and the concentrations were determined using a validated analytical method after a pre-concentration step. Methadone measured in all samples and there are correlations between administered dose of methadone and its serum and urine concentrations. A weak correlation is observed between dose and EBC concentration. Wider variations in EBC concentrations of methadone could be justified concerning a number of affecting parameters such as relative humidity of the collection area and further investigations are required for standardization of EBC as a non-invasive biological sample to be used in clinical practice.
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
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RO201904281905225ZK.pdf | 436KB | download |