Effect of Naturally Occurring Ozone Air Pollution Episodes on Pulmonary Oxidative Stress and Inflammation

International Journal of Environmental Research and Public Health

Cheryl Pirozzi¹  Anne Sturrock¹  Hsin-Yi Weng²  Tom Greene³  Mary Beth Scholand¹  Richard Kanner¹  Robert Paine¹ 

[1] Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Utah, 26 North 1900 East, Salt Lake City, UT 84132, USA; E-Mails:;Department of Pediatrics, University of Utah, Salt Lake City, UT 84132, USA; E-Mail:;Department of Internal Medicine, Division of Epidemiology, University of Utah, Salt Lake City, UT 84132, USA; E-Mail:

关键词: air pollution;    ozone;    chronic obstructive pulmonary disease;    exhaled breath condensate;    oxidative stress;    airway inflammation;   

DOI  :  10.3390/ijerph120505061

来源: mdpi

【 摘 要 】

This study aimed to determine if naturally occurring episodes of ozone air pollution in the Salt Lake Valley in Utah, USA, during the summer are associated with increased pulmonary inflammation and oxidative stress, increased respiratory symptoms, and decreased lung function in individuals with chronic obstructive pulmonary disease (COPD) compared to controls. We measured biomarkers (nitrite/nitrate (NO_x), 8-isoprostane) in exhaled breath condensate (EBC), spirometry, and respiratory symptoms in 11 former smokers with moderate-to-severe COPD and nine former smokers without airflow obstruction during periods of low and high ozone air pollution. High ozone levels were associated with increased NO_x in EBC in both COPD (8.7 (±8.5) vs. 28.6 (±17.6) μmol/L on clean air vs. pollution days, respectively, p < 0.01) and control participants (7.6 (±16.5) vs. 28.5 (±15.6) μmol/L on clean air vs. pollution days, respectively, p = 0.02). There was no difference in pollution effect between COPD and control groups, and no difference in EBC 8-isoprostane, pulmonary function, or respiratory symptoms between clean air and pollution days in either group. Former smokers both with and without airflow obstruction developed airway oxidative stress and inflammation in association with ozone air pollution episodes.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.