Oxidants and the pathogenesis of lung diseases

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:122

Review

Ciencewicki, Jonathan¹  Trivedi, Shweta¹  Kleeberger, Steven R.¹ 

[1] NIEHS, Lab Resp Biol, NIH, Res Triangle Pk, NC 27709 USA

关键词: oxidative stress;    antioxidant;    genetics;    susceptibility;    infant;    reproductive outcome;    premature;    children;    elderly;    asthma;    chronic obstructive pulmonary disease;    ozone;    pollutants;    particulates;    PM;    acute respiratory distress syndrome;    hyperoxia;    SNP;    single nucleotide polymorphism;   

DOI  :  10.1016/j.jaci.2008.08.004

来源: Elsevier

【 摘 要 】

The increasing number of population-based and epiderniologic associations between oxidant pollutant exposures and cardiopulmonary disease exacerbation, decrements in pulmonary function, and mortality underscores the important detrimental effects of oxidants on public health. Because inhaled oxidants initiate a number of pathologic processes, including inflammation of the airways, which may contribute to the pathogenesis and/or exacerbation of airways disease, it is critical to understand the mechanisms through which exogenous and endogenous oxidants interact with molecules in the cells, tissues, and epithelial lining fluid of the lung. Furthermore, it is clear that interindividual variation in response to a given exposure also exists across an individual lifetime. Because of the potential impact that oxidant exposures may have on reproductive outcomes and infant, child, and adult health, identification of the intrinsic and extrinsic factors that may influence susceptibility to oxidants remains an important issue. In this review, we discuss mechanisms of oxidant stress in the lung, the role of oxidants in lung disease pathogenesis and exacerbation (eg, asthma, chronic obstructive pulmonary disease, and acute respiratory distress syndrome), and the potential risk factors (eg, age, genetics) for enhanced susceptibility to oxidant-induced disease.

【 授权许可】

Free