Risk Factors Influencing the Oxidative Stress in Surgical Therapy of Skin Grafts

Current Health Sciences Journal

NICOLAE CORINA IVONAreplacement¹ 

关键词: burn trauma;    oxidative stress;    malondialdehyde;    antioxidants;    skin grafts;   

DOI  :  10.12865/CHSJ.37.03.03

学科分类：医学（综合）

来源: Universitatea de Medicina si Farmacie din Craiova / University of Medicine and Pharmacy

【 摘 要 】

Recent experimental data sustain that twenty-four hours postburn, mitochondrial outer membrane damage was progressively increased and cytosolic cytochrome-c gradually accumulated to approximately three times more, indicating impaired mitochondrial integrity. Maximal decrease of mitochondrial SOD activity occurred 8 hours postburn, maximal decrease in glutathione peroxidase activity persisted 2–24 h postburn. Lipid peroxidation increased, suggesting burn-induced oxidative stress. Administration of antioxidant vitamin therapy prevents burn-related loss of membrane integrity and antioxidant defense in mitochondria and prevents organic dysfunction. Lipid peroxidation could be measured in mitochondria, by means of malondialdehyde level, which assess oxidative stress. The mitochondrial outer membrane damage and cytochrome-c translocation estimate mitochondrial integrity, and activities of SOD and glutathione peroxidase evaluate mitochondrial antioxidant defense. We used this data for obser.

【 授权许可】

Unknown