Association between Prediagnostic Allergy-Related Serum Cytokines and Glioma

PLoS One

Adam Brandemihl¹  Brett Burkholder²  Michal Seweryn²  Samuel K. Handelman³  Grzegorz A. Rempala⁴  Henrik Kallberg⁵  Christopher Holloman⁵  Judith Schwartzbaum⁶  Ruo-Pan Huang⁶  Tom Borge Johannesen⁷  Randall Harris⁷  Maria Feychting⁸  Anders Ahlbom⁹  Tom K. Grimsrud⁹ 

[1] Center for Pharmacogenetics, Wexner Medical Center, Ohio State University, Columbus, Ohio, United States of America;Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America;Department of Mathematics, University of Lodz, Lodz, Poland;Department of Statistics, Ohio State University, Columbus, Ohio, United States of America;Division of Biostatistics, College of Public Health, Ohio State University, Columbus, Ohio, United States of America;Division of Epidemiology, College of Public Health, Ohio State University, Columbus, Ohio, United States of America;Mathematical Biosciences Institute, Columbus, Ohio, United States of America;RayBiotech, Inc. Guangzhou, China;RayBiotech, Inc., Norcross, Georgia, United States of America

关键词: Glioma;    Cancer detection and diagnosis;    Cytokines;    Serum proteins;    Glioblastoma multiforme;    Blood;    Allergies;    Transcription factors;   

DOI  :  10.1371/journal.pone.0137503

学科分类：医学（综合）

来源: Public Library of Science

【 摘 要 】

Allergy is inversely related to glioma risk. To determine whether prediagnostic allergy-related serum proteins are associated with glioma, we conducted a nested case-control study of seven cytokines (IL4, IL13, IL5, IL6, IL10, IFNG, TGFB2), two soluble cytokine receptors (sIL4RA, sIL13RA2) and three allergy-related transcription factors (FOXP3, STAT3, STAT6) using serum specimens from the Janus Serum Bank Cohort in Oslo, Norway. Blood donors subsequently diagnosed with glioma (n = 487) were matched to controls (n = 487) on age and date of blood draw and sex. We first estimated individual effects of the 12 serum proteins and then interactions between IL4 and IL13 and their receptors using conditional logistic regression. We next tested equality of case-control inter-correlations among the 12 serum proteins. We found that TGFB2 is inversely related to glioblastoma (Odds Ratio (OR) = 0.87, 95% Confidence Interval (CI)) = 0.76, 0.98). In addition, ≤ 5 years before diagnosis, we observed associations between IL4 (OR = 0.82, 95% CI = 0.66, 1.01), sIL4RA (OR = 0.80, 95% CI = 0.65, 1.00), their interaction (OR = 1.06, 95% CI = 1.01, 1.12) and glioblastoma. This interaction was apparent > 20 years before diagnosis (IL4-sIL4RA OR = 1.20, 95% CI = 1.05, 1.37). Findings for glioma were similar. Case correlations were different from control correlations stratified on time before diagnosis. Five years or less before diagnosis, correlations among case serum proteins were weaker than were those among controls. Our findings suggest that IL4 and sIL4RA reduce glioma risk long before diagnosis and early gliomagenesis affects circulating immune function proteins.

【 授权许可】

CC BY