Innate Immunity | |
Manipulation of innate immunity by a bacterial secreted peptide: Lantibiotic nisin Z is selectively immunomodulatory: | |
JasonKindrachuk1  | |
关键词: Antimicrobial peptide; immunomodulatory; innate immunity; lantibiotic; nisin; | |
DOI : 10.1177/1753425912461456 | |
学科分类:生物科学(综合) | |
来源: Sage Journals | |
【 摘 要 】
Innate immunity is triggered by a variety of bacterial molecules, resulting in both protective and potentially harmful pro-inflammatory responses. Further, innate immunity also provides a mechanism for the maintenance of homeostasis between the host immune system and symbiotic or non-pathogenic microorganisms. However, the bacterial factors that mediate these protective effects have been incompletely defined. Here, it was demonstrated that the lantiobiotic nisin Z is able to modulate host immune responses and mediate protective host immunity. Nisin Z induced the secretion of the chemokines MCP-1, IL-8 and Gro-α, and significantly reduced TNF-α induction in response to bacterial LPS in human PBMC. The results correlated with the ability of nisin Z to confer protection against both the Gram-positive organism Staphylococcus aureus, and the Gram-negatives Salmonella enterica sv. Typhimurium and Escherichia coli in murine challenge models. Mechanistic studies revealed that nisin Z modulates host immunity throu...
【 授权许可】
CC BY
【 预 览 】
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RO201904023421957ZK.pdf | 476KB | download |