Ontogeny of intestinal epithelial innate immune responses

Frontiers in Immunology

卷:5

Marcus eFulde¹  Mathias W. Hornef² 

[1] Hannover Medical School;

[2] RWTH University;

关键词: Infection;    Inflammation;    Antimicrobial peptide;    development;    innate immunity;    mucosal immunology;   

DOI  :  10.3389/fimmu.2014.00474

来源: DOAJ

【 摘 要 】

Emerging evidence indicates that processes during postnatal development might significantly influence the establishment of mucosal host-microbial homeostasis. Developmental and adaptive immunological processes but also environmental and microbial exposure early after birth might thus impact on diseases susceptibility and health during adult life. The present review aims at summarizing the current understanding of the intestinal epithelial innate immune system and its developmental and adaptive changes after birth.

【 授权许可】

Unknown