Electrospun polymeric dressings functionalized with antimicrobial peptides and collagen type I for enhanced wound healing

17th World Textile Conference AUTEX 2017 - Shaping the Future of Textiles

Felgueiras, H.P.^1 ; Amorim, M.T.P.^1

Centre for Textile Science and Technology, Department of Textile Engineering, University of Minho, Campus de Azurém, Guimaraes

4800-058, Portugal^1

关键词: Active compounds;    Antimicrobial peptide;    Collagen type I;    Electrospinning techniques;    Electrospun mats;    Medical textiles;    Therapeutic potentials;    Wound dressings;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/254/6/062004/pdf
DOI  :  10.1088/1757-899X/254/6/062004

来源: IOP

【 摘 要 】

Modern wound dressings combine medical textiles with active compounds that stimulate wound healing while protecting against infection. Electrospun wound dressings have been extensively studied and the electrospinning technique recognized as an efficient approach for the production of nanoscale fibrous mats. The unique diverse function and architecture of antimicrobial peptides (AMPs) has attracted considerable attention as a tool for the design of new anti-infective drugs. Functionalizing electrospun wound dressings with these AMPs is nowadays being researched. In the present work, we explore these new systems by highlighting the most important characteristics of electropsun wound dressings, revealing the importance of AMPs to wound healing, and the methods available to functionalize the electrospun mats with these molecules. The combined therapeutic potential of collagen type I and these AMP functionalized dressings will be highlighted as well; the significance of these new strategies for the future of wound healing will be clarified.