Serum cross-linked n-telopeptides of type 1 collagen (NTx) in patients with solid tumors

Sao Paulo Medical Journal

Fernando Jablonka²  Fernanda Schindler¹  Paula Philbert Lajolo¹  Hélio Pinczowski¹  Fernando Luiz Affonso Fonseca¹  Antônio Barbieri¹  Luiz Henrique Massonetto¹  Fábio Tadashi Katto¹  Auro Del Giglio¹ 

[1] ,Fundação e Faculdade de Medicina do ABCSanto André São Paulo ,Brazil

关键词: Bone neoplasms;    Radionuclide imaging;    Predictive value of tests;    Alkaline phosphatase;    Collagen type I;    Neoplasias ósseas;    Cintilografia;    Valor preditivo dos testes;    Fosfatase alcalina;    Colágeno tipo I;   

DOI  :  10.1590/S1516-31802009000100005

来源: SciELO

【 摘 要 】

CONTEXT AND OBJECTIVE: Cross-linked N-telopeptides of type I collagen (NTx) increase in concentration in situations in which bone resorption is increased, such as osteoporosis and bone metastasis (BM). We aimed to evaluate the serum concentrations of NTx in a sample of patients with several types of solid tumors. DESIGN AND SETTING: Cross-sectional analytical study with a control group in a tertiary public hospital. METHODS: We performed the quantitative enzyme-linked immunosorbent assay (ELISA) on serum NTx levels in 19 subjects without a history of cancer and 62 patients with various solid tumors who had been referred for a bone scan. Three experienced analysts read all bone scans. RESULTS: The serum NTx levels in patients with cancer and BM, with cancer but without BM and without cancer were 46.77 ± 2.58, 32.85 ± 2.05 and 22.32 ± 2.90 respectively (P < 0.0001). We did not find any significant correlations of serum NTx with age, gender, history of bone pain, tumor type and bone alkaline phosphatase levels. We found a significant correlation between serum NTx and alkaline phosphatase levels (R² = 0.08; P = 0.022). CONCLUSIONS: Serum NTx levels are significantly higher in patients with solid tumors and bone metastases than they are in patients without bone metastases and in normal controls.

【 授权许可】

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