Degradation of type I and II collagen by human C1̄s

FEBS Letters

Sakiyama, Hisako²  Matsumoto, Misako²  Moriya, Hideshige³  Yamaguchi, Kiichiro¹  Sakiyama, Shigeru⁴ 

[1] Division of Physiology and Pathology, National Institute of Radiological Sciences, 4-9-1 Anagawa, Chiba 260, Japan;The Department of Immunology, The Center for Adult Diseases, Osaka, Higashinari-ku, Osaka 537, Japan;The Department of Orthopaedics, Chiba University School of Medicine, 1-8-1 Inohana, Chiba 280, Japan;Division of Biochemistry. Chiba Cancer Center, Research Institute, 666-2 Nitona, Chiba 280, Japan

关键词: C1̄s;    Collagen type I;    Collagen type II;    CASP;    calcium-dependent serine proteinase;    AGLNE;    acetyl-Gly-L-Lys-naphthyl ester;    DFP;    diisopropyl fluorophosphate;   

DOI  :  10.1016/0014-5793(90)81009-D

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The activated first component of human complement, C1̄s, was shown to cleave type I and II collagen and gelatin. The proteolytic activity was heat labile and was inhibited by a monoclonal antibody (M241) which recognized light chain of active human C1s or by a serine protease inhibitor, DFP, but not by a chelating agent.

【 授权许可】

Unknown