Vitamin D and its role in coronavirus disease 2019 (COVID-19)

Journal of Diabetology

关键词: ace-2;    corona;    covid-19;    diabetes;    immunomodulatory;    innate immunity;    prediabetes;    respiratory tract infections;    sars-cov-2;    spike protein;    vitamin d;   

DOI  :  10.4103/JOD.JOD_18_20

来源: DOAJ

【 摘 要 】

The unprecedented (in scale, scope) coronavirus disease 2019 (COVID-19) pandemic has taken the world by storm. Cases and case fatality rates are mounting and in this panic-stricken environment, where there are no specific antinovel corona viral drugs or vaccines, doctors are experimenting with drugs that have not been specifically approved for this virus. Against this backdrop, a review article has been written based on locating, selecting, extracting, and synthesizing relevant available in vitro and clinical data on the use of vitamin D as an innate immunity boosting agent, and its possible effects in certain viral (including corona viral) and other acute respiratory tract infections. Vitamin D is not only a micronutrient or vitamin, but also a hormone that has vitamin D receptors on cells all over the body. Vitamin D deficiency/insufficiency is a pandemic, though not infectious, and correcting vitamin D deficiency or insufficiency is required. Whether vitamin D has specific effects against this novel coronavirus in patients with COVID-19 is not known, as there is no randomized controlled clinical trial on its use in such patients. Perhaps there is need for research in this area and particularly when people cannot get adequately exposed to the sun due to the lockdown, taking vitamin D supplements may help them become vitamin D sufficient. Whether it will be sufficient in their fight against COVID-19 is a question that needs to be answered through appropriate research.

【 授权许可】

Unknown