Incidence of Co-Infections of HIV, Herpes Simplex Virus Type 2 and Syphilis in a Large Cohort of Men Who Have Sex with Men in Beijing, China

PLoS One

Xiao Qi¹  Zheng Zhang¹  Fengji Luo¹  Xueying Yang²  Joseph T. F. Lau²  Dongliang Li²  Zixin Wang²  Yuhua Ruan²  Chunrong Li³  Yunhua Zhou⁴ 

[1] Center for Health Behaviours Research, The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong SAR, Hong Kong, China;Chaoyang Center for Disease Control and Prevention, Beijing, PR China;Department of Epidemiology and Health Statistics, School of Public Health, Soochow University, Suzhou, Jiangsu, China;State Key Laboratory for Infectious Disease Prevention and Control (SKLID), Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China

关键词: Co-infections;    Syphilis;    HIV;    HIV epidemiology;    HIV diagnosis and management;    HIV prevention;    Men who have sex with men;    China;   

DOI  :  10.1371/journal.pone.0147422

学科分类：医学（综合）

来源: Public Library of Science

【 摘 要 】

Background The HIV-epidemic among MSM in China has worsened. In this key population, prevalence of HSV-2 and syphilis infection and co-infection with HIV is high. Methods A longitudinal study was conducted (n = 962) in Beijing, China, with three overlapping cohorts (n = 857, 757 and 760) consisting of MSM that were free from pairs of infections of concern (i.e. HIV-HSV-2, HIV-syphilis, HSV-2-syphilis) at baseline to estimate incidence of HIV, HSV-2, syphilis, and those of co-infection. Results The incidence of HIV, HSV-2 and syphilis in the overall cohort was 3.90 (95% CI = 2.37, 5.43), 7.87 (95% CI = 5.74, 10.00) and 6.06 (95% CI = 4.18, 7.94) cases per 100 person-years (PYs), respectively. The incidence of HIV-HSV-2, HIV-Syphilis and HSV-2-Syphilis co-infections was 0.30 (95% CI = 0.29, 0.88), 1.02 (95% CI = 0.13, 2.17) and 1.41 (95% CI: 0.04, 2.78) cases per 100 PYs, respectively, in the three sub-cohorts constructed for this study. Conclusions The incidence of HIV, HSV-2 and syphilis was very high and those of their co-infections were relatively high. Such co-infections have negative impacts on the HIV/STI epidemics. Prevention practices need to take such co-infections into account.

【 授权许可】

CC BY