Carcinogenesis induced by low-dose radiation

Radiology and Oncology

Dr. Katarzyna Kulcenty¹  Julian Malicki²  Marta Kruszyna-Mochalska²  Agnieszka Skrobała²  Anna Kowalik³  Małgorzata Skórska³  Wiktoria Maria Suchorska⁴  Igor Piotrowski⁵  Weronika Jackowiak⁶ 

[1] Corresponding authorRadiobiology Laboratory, Department of Medical Physics, Greater Poland Cancer Centre, Garbary 15 Street, Poznań, PolandDepartment of Electroradiology, University of Medical Sciences, Poznań, Poland;Department of Electroradiology, University of Medical Sciences, Poznań, PolandDepartment of Medical Physics, Greater Poland Cancer Centre, Poznań, PolandOther articles by this author:;Department of Medical Physics, Greater Poland Cancer Centre, Poznań, PolandOther articles by this author:;Radiobiology Laboratory, Department of Medical Physics, Greater Poland Cancer Centre, Garbary 15 Street, Poznań, PolandDepartment of Electroradiology, University of Medical Sciences, Poznań, PolandOther articles by this author:;Radiobiology Laboratory, Department of Medical Physics, Greater Poland Cancer Centre, Garbary 15 Street, Poznań, PolandOther articles by this author:;Radiotherapy Ward I, Greater Poland Cancer Centre, Poznań, PolandOther articles by this author:

关键词: low-dose radiation;    carcinogenesis;    DNA;    radiation induced bystander effect;   

DOI  :  10.1515/raon-2017-0044

学科分类：肿瘤学

来源: Onkoloski Institut Ljubljana / Institute of Oncology Ljubljana

【 摘 要 】

BackgroundAlthough the effects of high dose radiation on human cells and tissues are relatively well defined, there is no consensus regarding the effects of low and very low radiation doses on the organism. Ionizing radiation has been shown to induce gene mutations and chromosome aberrations which are known to be involved in the process of carcinogenesis. The induction of secondary cancers is a challenging long-term side effect in oncologic patients treated with radiation. Medical sources of radiation like intensity modulated radiotherapy used in cancer treatment and computed tomography used in diagnostics, deliver very low doses of radiation to large volumes of healthy tissue, which might contribute to increased cancer rates in long surviving patients and in the general population. Research shows that because of the phenomena characteristic for low dose radiation the risk of cancer induction from exposure of healthy tissues to low dose radiation can be greater than the risk calculated from linear no-threshold model. Epidemiological data collected from radiation workers and atomic bomb survivors confirms that exposure to low dose radiation can contribute to increased cancer risk and also that the risk might correlate with the age at exposure.

【 授权许可】

Unknown