International Journal of Molecular Sciences | |
Rescue Effects: Irradiated Cells Helped by Unirradiated Bystander Cells | |
R. K. K. Lam1  Y. K. Fung1  W. Han2  K. N. Yu1  | |
[1] Department of Physics and Materials Science, City University of Hong Kong, Kowloon, Hong Kong; E-Mails:;Center of Medical Physics and Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China; E-Mail: | |
关键词: radioimmunotherapy; rescue effect; radiation induced bystander effect; intercellular signaling; | |
DOI : 10.3390/ijms16022591 | |
来源: mdpi | |
【 摘 要 】
The rescue effect describes the phenomenon where irradiated cells or organisms derive benefits from the feedback signals sent from the bystander unirradiated cells or organisms. An example of the benefit is the mitigation of radiation-induced DNA damages in the irradiated cells. The rescue effect can compromise the efficacy of radioimmunotherapy (RIT) (and actually all radiotherapy). In this paper, the discovery and subsequent confirmation studies on the rescue effect were reviewed. The mechanisms and the chemical messengers responsible for the rescue effect studied to date were summarized. The rescue effect between irradiated and bystander unirradiated zebrafish embryos
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
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