Rab3Gap1 mediates exocytosis of Claudin-1 and tight junction formation during epidermal barrier acquisition

Developmental biology

G.Youssef¹ 

关键词: Rab3Gap1;    Epidermis;    Epidermal barrier;    Signalling;    Keratinocyte;   

DOI  :  10.1016/j.ydbio.2013.04.034

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

Epidermal barrier acquisition during late murine gestation is accompanied by an increase in Akt kinase activity and cJun dephosphorlyation. The latter is directed by the Ppp2r2a regulatory subunit of the Pp2a phosphatase. This was accompanied by a change of Claudin-1 localisation to the cell surface and interaction between Occludin and Claudin-1 which are thought to be required for tight junction formation.

【 授权许可】

CC BY