期刊论文详细信息
Frontiers in Cellular and Infection Microbiology
Streptococcal Cysteine Protease-Mediated Cleavage of Desmogleins Is Involved in the Pathogenesis of Cutaneous Infection
Yamaguchi, Masaya1  Honda-Ogawa, Mariko1  Terao, Yutaka1  Nakagawa, Seitaro2  Mori, Yasushi2  Matsue, Hiroyuki2  Sumitomo, Tomoko2  Kawabata, Shigetada2  Nakata, Masanobu3  Nakamura, Yuumi4 
[1] Department of Dermatology, Chiba University Graduate School of Medicine, Japan;Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Japan;Division of Microbiology and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Japan;Division of Special Care Dentistry, Osaka University Dental Hospital, Japan
关键词: Streptococcus pyogenes;    Epidermal barrier;    Cutaneous infection;    Desmogleins;    SpeB;   
DOI  :  10.3389/fcimb.2018.00010
学科分类:生物科学(综合)
来源: Frontiers
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【 摘 要 】

Streptococcus pyogenes is responsible for a wide variety of cutaneous infections ranging from superficial impetigo to fulminant invasive necrotizing fasciitis. Dysfunction of desmosomes is associated with the pathogenesis of cutaneous diseases. We identified streptococcal pyrogenic exotoxin B (SpeB) as a proteolytic factor that cleaves the extracellular domains of desmoglein 1 and 3. In an epicutaneous infection model, lesional skin infected with an speB deletion mutant were significantly smaller as compared to those caused by the wild-type strain. Furthermore, immunohistological analysis indicated cleavage of desmogleins that developed around the invasion site of the wild-type strain. In contrast, the speB mutant was preferentially found on the epidermis surface layer. Taken together, our findings provide evidence that SpeB-mediated degradation of desmosomes has a pathogenic role in development of S. pyogenes cutaneous infection.

【 授权许可】

CC BY   

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