Frontiers in Cellular and Infection Microbiology | |
Streptococcal Cysteine Protease-Mediated Cleavage of Desmogleins Is Involved in the Pathogenesis of Cutaneous Infection | |
Yamaguchi, Masaya1  Honda-Ogawa, Mariko1  Terao, Yutaka1  Nakagawa, Seitaro2  Mori, Yasushi2  Matsue, Hiroyuki2  Sumitomo, Tomoko2  Kawabata, Shigetada2  Nakata, Masanobu3  Nakamura, Yuumi4  | |
[1] Department of Dermatology, Chiba University Graduate School of Medicine, Japan;Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Japan;Division of Microbiology and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Japan;Division of Special Care Dentistry, Osaka University Dental Hospital, Japan | |
关键词: Streptococcus pyogenes; Epidermal barrier; Cutaneous infection; Desmogleins; SpeB; | |
DOI : 10.3389/fcimb.2018.00010 | |
学科分类:生物科学(综合) | |
来源: Frontiers | |
【 摘 要 】
Streptococcus pyogenes is responsible for a wide variety of cutaneous infections ranging from superficial impetigo to fulminant invasive necrotizing fasciitis. Dysfunction of desmosomes is associated with the pathogenesis of cutaneous diseases. We identified streptococcal pyrogenic exotoxin B (SpeB) as a proteolytic factor that cleaves the extracellular domains of desmoglein 1 and 3. In an epicutaneous infection model, lesional skin infected with an speB deletion mutant were significantly smaller as compared to those caused by the wild-type strain. Furthermore, immunohistological analysis indicated cleavage of desmogleins that developed around the invasion site of the wild-type strain. In contrast, the speB mutant was preferentially found on the epidermis surface layer. Taken together, our findings provide evidence that SpeB-mediated degradation of desmosomes has a pathogenic role in development of S. pyogenes cutaneous infection.
【 授权许可】
CC BY
【 预 览 】
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