Evaluation of QTc Interval Prolongation in Breast Cancer Patients after Treatment with Epirubicin, Cyclophosphamide, and Docetaxel and the Influence of Interobserver Variation

Breast care

Julian Puppe¹ 

关键词: Breast cancer;    Chemotherapy;    Anthracyclines;    Epirubicin;    Cardiotoxicity;    QT prolongation;   

DOI  :  10.1159/000455065

学科分类：泌尿医学

来源: S Karger AG

【 摘 要 】

In this study we assessed the effect of epirubicin, cyclophosphamide, and docetaxel (EC-Doc) on the QTc interval in 10 patients with early breast cancer. Cardiac toxicity was assessed with symptoms, transthoracic echocardiography, electrocardiography (ECG), and serum cardiac markers at baseline and after 4 cycles of EC and 4 cycles of docetaxel. To evaluate the influence of interobserver variation, the QTc interval was analyzed by a cardiologist, a gynecologist, and with automated ECG interpretation software.

【 授权许可】

CC BY