The RP105/MD-1 complex: molecular signaling mechanisms and pathophysiological implications

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

Blumenthal, Antje² 

[1] and..Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Queensland, Australia;The University of Queensland Diamantina Institute, Translational Research Institute, The University of Queensland, Brisbane, Queensland, Australia

关键词: B cells;    macrophages;    infection;    inflammation;    autoimmunity;   

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Radioprotective 105 kDa (CD180) is an unusual TLR that lacks an intracellular Toll-IL-1R signaling domain and exhibits unconventional homodimerization behavior. Differential expression and functions of radioprotective 105 kDa have been associated with immune-mediated pathologies, including infection, chronic inflammation, and autoimmune disorders. Radioprotective 105 kDa activates macrophages and B cells independently of canonical TLR signaling. Current understanding of the functional consequences of radioprotective 105 kDa signaling in B cells, macrophages, and dendritic cells indicates overlapping, but also some apparent opposing, cell-specific roles for radioprotective 105 kDa in shaping cellular functions. This review compares interactions of radioprotective 105 kDa with its coreceptors, CD19, TLR4, and TLR2; integrates recent, novel findings on radioprotective 105 kDa-mediated molecular signaling mechanisms; and summarizes current understanding of its contributions to infectious, inflammatory, and autoimmune disease.

【 授权许可】

CC BY