DNA-Origami-Aided Lithography for Sub-10 Nanometer Pattern Printing

Proceedings

Gállego, Isaac¹ 

关键词: DNA nanotechnology;    lithography;    nanopatterning;    gold nanoparticles;    metasurfaces;   

DOI  :  10.3390/proceedings1040325

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

We report the first DNA-based origami technique that can print addressable patterns on surfaces with sub-10 nm resolution. Specifically, we have used a two-dimensional DNA origami as a template (DNA origami stamp) to transfer DNA with pre-programmed patterns (DNA ink) on gold surfaces. The DNA ink is composed of thiol-modified staple strands incorporated at specific positions of the DNA origami stamp to create patterns upon thiol-gold bond formation on the surface (DNA ink). The DNA pattern formed is composed of unique oligonucleotide sequences, each of which is individually addressable. As a proof-of-concept, we created a linear pattern of oligonucleotide-modified gold nanoparticles complementary to the DNA ink pattern. We have developed an in silico model to identify key elements in the formation of our DNA origami-driven lithography and nanoparticle patterning as well as simulate more complex nanoparticle patterns on surfaces.

【 授权许可】

CC BY