Strategies in ‘snake venomics’ aiming at an integrative view of compositional, functional, and immunological characteristics of venoms

Journal of venomous animals and toxins

Bruno Lomonte²  Juan J. Calvete⁴ 

[1] , Costa Rica;Instituto Clodomiro Picado, Facultad de MicrobiologíStructural and Functional Venomics Laboratory, Instituto de Biomedicina de Valencia, CSIC, Valencia, Spain;a, Universidad de Costa Rica, San José

关键词: Snake venoms;    Proteomics;    Venomics;    Antivenomics;    Toxicovenomics;   

DOI  :  10.1186/s40409-017-0117-8

学科分类：药理学

来源: BioMed Central

【 摘 要 】

This work offers a general overview on the evolving strategies for the proteomic analysis of snake venoms, and discusses how these may be combined through diverse experimental approaches with the goal of achieving a more comprehensive knowledge on the compositional, toxic, and immunological characteristics of venoms. Some recent developments in this field are summarized, highlighting how strategies have evolved from the mere cataloguing of venom components (proteomics/venomics), to a broader exploration of their immunological (antivenomics) and functional (toxicovenomics) characteristics. Altogether, the combination of these complementary strategies is helping to build a wider, more integrative view of the life-threatening protein cocktails produced by venomous snakes, responsible for thousands of deaths every year.

【 授权许可】

CC BY