Bothrops atrox, the most important snake involved in human envenomings in the amazon: How venomics contributes to the knowledge of snake biology and clinical toxinology

Toxicon: X

Pedro Ferreira Bisneto¹  Fernando Val²  Igor L. Kaefer³  Marco Aurélio Sartim⁴  Ana Maria Moura-da-Silva⁴  Jorge Carlos Contreras-Bernal⁴  Iran Mendonça da Silva⁴  Paulo Sérgio Bernarde⁴  Felipe Gobbi Grazziotin⁵  Lisele Brasileiro⁶  Jacqueline Sachett⁶  Fan Hui Wen⁶  Wuelton Marcelo Monteiro⁶  Allyson Guimarães da Costa⁶  Sâmella Silva-de-Oliveira⁶  Marcus Lacerda⁷ 

[1] Corresponding author. Escola Superior de Ciências da Saúde, Universidade do Estado do Amazonas, Manaus, Brazil.;Diretoria de Ensino e Pesquisa, Fundação Alfredo da Matta, Manaus, Brazil;;Instituto Leônidas &Instituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil;Maria Deane, Manaus, Brazil;Escola Superior de Ciências da Saúde, Universidade do Estado do Amazonas, Manaus, Brazil;Programa de Pós-Graduação em Zoologia, Instituto de Ciências Biológicas, Universidade Federal do Amazonas, Manaus, Brazil;

关键词: Common lancehead;    Envenoming;    Venomics;    Antivenomics;    Antivenom;    Viperidae;   

DOI  :  

来源: DOAJ

【 摘 要 】

Bothrops atrox snakes are mostly endemic of the Amazon rainforest and is certainly the South American pit viper responsible for most of the snakebites in the region. The composition of B. atrox venom is significantly known and has been used to trace the relevance of the venom phenotype for snake biology and for the impacts in the clinics of human patients involved in accidents by B. atrox. However, in spite of the wide distribution and the great medical relevance of B. atrox snakes, B. atrox taxonomy is not fully resolved and the impacts of the lack of taxonomic resolution on the studies focused on venom or envenoming are currently unknown. B. atrox venom presents different degrees of compositional variability and is generally coagulotoxic, inducing systemic hematological disturbances and local tissue damage in snakebite patients. Antivenoms are the effective therapy for attenuating the clinical signs. This review brings a comprehensive discussion of the literature concerning B. atrox snakes encompassing from snake taxonomy, diet and venom composition, towards clinical aspects of snakebite patients and efficacy of the antivenoms. This discussion is highly supported by the contributions that venomics and antivenomics added for the advancement of knowledge of B. atrox snakes, their venoms and the treatment of accidents they evoke.

【 授权许可】

Unknown