Proteomics, toxicity and antivenom neutralization of Sri Lankan and Indian Russell’s viper ( Daboia russelii ) venoms

Journal of venomous animals and toxins

article

Tasnim Faisal¹  Kae Yi Tan²  Nget Hong Tan²  Si Mui Sim¹  Christeine Ariaranee Gnanathasan³  Choo Hock Tan¹ 

[1] Department of Pharmacology, Faculty of Medicine, University ofMalaya;Department of Molecular Medicine, Faculty of Medicine, University ofMalaya;Department of Clinical Medicine, Faculty of Medicine, University ofColombo

关键词: Geographical variation;    Venomics;    Antivenomics;    Antivenom potency;   

DOI  :  10.1590/1678-9199-JVATITD-2020-0177

学科分类：药理学

来源: BioMed Central

【 摘 要 】

Background: The western Russell’s viper ( Daboia russelii ) is widely distributed in South Asia, and geographical venom variation is anticipated among distant populations. Antivenoms used for Russell’s viper envenomation are, however, raised typically against snakes from Southern India. The present study investigated and compared the venom proteomes of D. russelii from Sri Lanka (DrSL) and India (DrI), the immunorecognition of Indian VINS Polyvalent Antivenom (VPAV) and its efficacy in neutralizing the venom toxicity.

【 授权许可】

CC BY