Determination of 3,4-methylenedioxymethamphetamine (MDMA) in Ecstasy tablets by high performance liquid chromatography with fluorescence detection (HPLC-FD)

Quimica nova

Costa, José Luiz da¹  Pintao, Estela Regina¹  Negrini Neto, Osvaldo¹  Corrigliano, Célia Maria Castro¹ 

[1] Superintendência da Polícia Técnico Científica do Estado de São Paulo, São Paulo, Brasil

关键词: HPLC;    MDMA;    drugs of abuse.;   

DOI  :  10.1590/S0100-40422009000400026

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

This paper describesthe development and validation of simple and selective analytical method fordetermination of 3.4-methylenedioxymethamphetamine (MDMA) in Ecstasytablets, using high performance liquid chromatography with fluorescence detection.Analysis was performed in a reversed phase column (LiChrospher 100 C18, 150x 4.6 mm, 5 µm), isocratic elution with phosphate buffer 25 mmol/L pH 3.0and acetonitrile (95:5, v/v). The method presents adequate linearity, selectivity,precision and accuracy. MDMA concentration in analyzed tablets showed a remarkablevariability (from 8.5 to 59.5 mg/tablet) although the tablet weights were uniform,indicating poor manufacturing control thus imposing additional health risksto the users.

【 授权许可】

CC BY