Determinação de 3,4-metilenodioximetanfetamina (MDMA) em comprimidos de Ecstasy por cromatografia líquida de alta eficiência com detecção por fluorescência (CLAE-DF)

Química Nova

José Luiz Da Costa¹  Estela Regina Pintao¹  Célia Maria Castro Corrigliano¹  Osvaldo Negrini Neto¹ 

[1] ,Superintendência da Polícia Técnico Científica do Estado de São Paulo Instituto de Criminalística Centro de Exames, Análises e PesquisasSão Paulo SP ,Brasil

关键词: HPLC;    MDMA;    drugs of abuse;   

DOI  :  10.1590/S0100-40422009000400026

来源: SciELO

【 摘 要 】

This paper describes the development and validation of simple and selective analytical method for determination of 3.4-methylenedioxymethamphetamine (MDMA) in Ecstasy tablets, using high performance liquid chromatography with fluorescence detection. Analysis was performed in a reversed phase column (LiChrospher 100 C18, 150 x 4.6 mm, 5 µm), isocratic elution with phosphate buffer 25 mmol/L pH 3.0 and acetonitrile (95:5, v/v). The method presents adequate linearity, selectivity, precision and accuracy. MDMA concentration in analyzed tablets showed a remarkable variability (from 8.5 to 59.5 mg/tablet) although the tablet weights were uniform, indicating poor manufacturing control thus imposing additional health risks to the users.

【 授权许可】

CC BY-NC   
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