Sensitivity of direct smear microscopy for the diagnosis of TB in high HIV prevalent population

Scientific Research and Essays

Onubogu Catherine Chizoba¹ 

关键词:  ;    Tuberculosis;    HIV;    acid fast bacilli;    direct smear microscopy;    culture.;   

DOI  :  10.5897/SRE11.712

学科分类：社会科学、人文和艺术（综合）

来源: Academic Journals

【 摘 要 】

Diagnosis of tuberculosis (TB) amongst HIV patients is a great challenge due to the low density of Acid Fast bacilli (AFB) in their sputum. The study was conducted to determine the sensitivity of direct smear microscopy (DSM) for TB diagnosis in HIV endemic setting using culture as a gold standard. During the period of study, 549 TB suspects were screened, and they comprised of 396(72%) HIV-positive and 153(28%) HIV-negative patients. Overall, TB positive rate was 221(40.3%), the rate by culture and DSM were 155(28.2%) and 12(2.2%) respectively. Among HIV-positive patients, the overall TB positive rate was 151(38.1%), while the rate by culture and DSM were 120(30.3%) and 7(1.7%) respectively (p = 0.0001). The overall positive rate for HIV-negative was 70(45.8%) and the rate by culture was 35(22.9%) and DSM was 5(3.3%) with p = 0.0004. The sensitivity of DSM in HIV- positive and negative population was 21.5 and 53.8% respectively. Findings from this study showed the low case detection rate of DSM as compared to culture, more especially in HIV positive persons. To improve case detection, we recommend the use of culture as back up to enhance the performance of DSM especially in HIV positive persons.

【 授权许可】

CC BY