A Yersinia Effector with Enhanced Inhibitory Activity on the NF-κB Pathway Activates the NLRP3/ASC/Caspase-1 Inflammasome in Macrophages

PLoS Pathogens

Kenneth B. Marcu¹  Ying Zheng²  Sarit Lilo²  Yue Zhang²  James B. Bliska³  Ruslan Medzhitov⁴  Igor E. Brodsky⁴ 

[1] Department of Biochemistry and Cell Biology, Stony Brook University,Stony Brook, New York, United States of America;Department of Molecular Genetics and Microbiology, Center for InfectiousDiseases, Stony Brook University, Stony Brook, New York, United States ofAmerica;Immunology and Genetics Department, Istituti Ortopedia Rizzoli, Bologna,Italy;Section of Immunobiology, Yale University School of Medicine, New Haven,Connecticut, United States of America

关键词: Macrophages;    Apoptosis;    Yersinia pestis;    Secretion;    Yersinia pseudotuberculosis;    Enzyme-linked immunoassays;    Transcription factors;    Inflammasomes;   

DOI  :  10.1371/journal.ppat.1002026

学科分类：生物科学（综合）

来源: Public Library of Science

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