Investigation the 'Trojan Horse' Mechanism of Yersinia pestis Virulence.

McCutchen-Maloney, S. L. ; Fitch, J. P.

Technical Information Center Oak Ridge Tennessee

关键词: Virulence;    Yersinia pestis;    Immunoglobulins;    Immunity;    Induction;   

RP-ID  :  DE2009957607

学科分类：工程和技术（综合）

美国|英语

来源: National Technical Reports Library

【 摘 要 】

This project focused on characterizing two novel mechanisms that regulate virulence factor induction in Y. pestis, immunoglobulin G (IgG) binding and quorum sensing, using a real-time reporter system to monitor induction of virulence. Incorporating a better understanding of the mechanisms of virulence and pathogenicity into detection systems, may allow us to anticipate both natural and engineered evolution of infectious diseases while laying the foundation for next-generation detection of biothreat agents.