Noise Cancellation: Viral Fine Tuning of the Cellular Environment for Its Own Genome Replication

PLoS Pathogens

Tatsuya Tsurumi¹  Yoshitaka Sato² 

[1] Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan;Division of Virology, Aichi Cancer Center Research Institute, Nagoya, Japan

关键词: Viral replication;    DNA replication;    DNA damage;    Phosphorylation;    Synthesis phase;    Epstein-Barr virus;    Kinase inhibitors;    Ubiquitin ligases;   

DOI  :  10.1371/journal.ppat.1001158

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Productive replication of DNA viruses elicits host cell DNA damage responses, which cause both beneficial and detrimental effects on viral replication. In response to the viral productive replication, host cells attempt to attenuate the S-phase cyclin-dependent kinase (CDK) activities to inhibit viral replication. However, accumulating evidence regarding interactions between viral factors and cellular signaling molecules indicate that viruses utilize them and selectively block the downstream signaling pathways that lead to attenuation of the high S-phase CDK activities required for viral replication. In this review, we describe the sophisticated strategy of Epstein-Barr virus to cancel such “noisy” host defense signals in order to hijack the cellular environment.

【 授权许可】

CC BY