Salmonella Modulation of Host Cell Gene Expression Promotes Its Intracellular Growth

PLoS Pathogens

Beile Gao¹  Jorge E. Galán¹  Sebastian Hannemann¹ 

[1] Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America

关键词: Salmonella typhimurium;    Salmonellosis;    Salmonella;    Gene expression;    Epithelial cells;    Intracellular pathogens;    Phosphorylation;    DNA transcription;   

DOI  :  10.1371/journal.ppat.1003668

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Salmonella Typhimurium has evolved a complex functional interface with its host cell largely determined by two type III secretion systems (T3SS), which through the delivery of bacterial effector proteins modulate a variety of cellular processes. We show here that Salmonella Typhimurium infection of epithelial cells results in a profound transcriptional reprogramming that changes over time. This response is triggered by Salmonella T3SS effector proteins, which stimulate unique signal transduction pathways leading to STAT3 activation. We found that the Salmonella-stimulated changes in host cell gene expression are required for the formation of its specialized vesicular compartment that is permissive for its intracellular replication. This study uncovers a cell-autonomous process required for Salmonella pathogenesis potentially opening up new avenues for the development of anti-infective strategies that target relevant host pathways.

【 授权许可】

CC BY